Safranal prevents rotenone-induced oxidative stress and apoptosis in an in vitro model of Parkinson's disease through regulating Keap1/Nrf2 signaling pathway

Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice

Objective(s): Ulcerative colitis (UC) is a kind of complex immune disease, and a major cause of destruction of intestinal barrier and oxidative stress in this field. In this paper, glutamine (Gln) was believed to offer protection against oxidative stress injury in colitis mice.Materials and Methods: Thirty mice were randomly assigned int...

crocin decreased acrylamide – induced neurotoxicity in wistar rat through oxidative stress and apoptosis pathway

Metal-Induced Oxidative Stress and Cellular Signaling Alteration in Animals

Contamination by heavy metals has attracted increasing attention considering the ability of these elements in producing serious consequence to ecosystem, and especially on animals health. Due to their widespread use in human activities such as industry, agriculture and even as medicine (e.g. arsenic, selenium and platinum), numerous health risks may be associated with exposure to these substanc...

Isolongifolene attenuates rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis.

The present study was carried out to investigate the neuroprotective effects of isolongifolene (ILF), a tricyclic sesquiterpene of Murraya koenigii, against rotenone-induced mitochondrial dysfunction, oxidative stress and apoptosis in a cellular model. SH-SY5Y human neuroblastoma cells were divided into four experimental groups (control, rotenone (100 nM), ILF (10 microM) + rotenone (100 nanoM)...

Allicin prevents H2O2-induced apoptosis of HUVECs by inhibiting an oxidative stress pathway

BACKGROUND Allicin, a primary ingredient of garlic, has been proposed to possess cardioprotective properties, which are commonly mediated by improved endothelial function. METHODS To investigate the effect and mechanism of allicin on the apoptosis of human umbilical vein endothelial cells (HUVECs), we used Propidium iodide (PI) staining and Annexin V/ PI staining assays to establish a model o...